top of page


Crystallization is a widely implemented process in the chemical industry production and purification stages of particulate products. Though a generally efficient process for purification, it is often a complex operation mainly due to the difficulty in obtaining reliable experimental data related to the properties of the particulate solid systems.

  • Continuous crystallization of Active Pharmaceutical Ingredients (APIs) 


Continuous manufacturing has been the norm in almost all manufacturing industries. The pharmaceutical industry, however, has so far shied away from the continuous model, instead of clinging onto batch manufacturing since the beginnings of the drug era. The heavy regulation has held back transformation in this field. However, with the constant economic changes during the last decade, the pressure on all parts of the pharmaceutical value chain has increased and the manufacturing efficiency starts to be the core of research. The development of continuous production technology for pharmaceutical industry becomes, by this way, a priority. In this research topic, it has been explored the applicability of the meso-OFR on the continuous crystallization of Active Pharmaceutical Ingredients (APIs) in collaboration with the industry.


Figure 1. Oscillatory flow reactor prototype based on plate arrangement.

  • ​Continuous crystallization of proteins

This research aims at investigating the applicability of a novel meso oscillatory flow reactor (meso-OFR) for the crystallization of proteins as a process step.

  • Antibodies crystallization

Credit - Getty Images

Antibodies are major components of humoral immunity. IgG is the main type of antibody found in blood and extracellular fluid allowing it to control infection of body tissues. In this research, we are focused on the IgG purification by crystallization. For that several operational conditions using an meso-OFR have been studied.  


bottom of page