© 2018 Meso-OFR research line

PROJECTS

CrystalFlow
Continuous crystallization of active pharmaceutical ingredients (APIs)
A. Ferreira (Principal Investigator) - 07/2016 - 06/2019
 

The aim of CrystalFlow project (PTDC/QEQ-PRS/3787/2014) is to explore the applicability of the novel meso-OFR based on SPC geometry at the industrial environment for continuous crystallization of active pharmaceutical ingredients (API) in order to obtain crystals with:

- high purity;

- high specific surface area (favoured by small crystal sizes);

- narrow crystal size distribution;

- low concentration of secondary products as polymorphic forms.

 

Mix&DryFast  
Development of efficient mixer and powder dryer continuous systems
A. Ferreira (Team member) - 11/2017 - 10/2019

 

Continuous Manufacturing is already well known in Chemical Industry and it enables the same throughput with a smaller footprint when compared with batch processes. Other benefits include higher productivity, greater energy efficiency, less wastes and, in some cases, less capital and operating costs.

Mix&DryFast project proposes two innovative approaches for continuously mixing solid particles in fluids and for drying difficult powder solids.

FCT Investigador
(IF/01087/2014)
A. Ferreira (Principal Investigator) - 01/2015 - 12/2019
 
The FCT Investigator Programme aims to create a talent base of scientific leaders, by providing 5-year funding for the most talented and promising researchers, across all scientific areas and nationalities. The FCT Investigator Programme is centred on the researcher and his research project.

 

ColOsH
Novel concept for a dynamic modular Colon system including peristalsis simulation by Oscillatory-flow and Colon-Host interaction
 
A. Ferreira (Principal Investigator at FEUP) - 07/2018 - 06/2021
 
There are many diseases associated to microbiota dysbiosis, e.g. diabetes,
inflammatory bowel, cancer. To study those diseases and effects of drugs/food
compounds in the microbiota and intestinal cells, several gastrointestinal in-vitro simulators have been developed. However, none of them combines in one system the peristaltic simulation with metabolites absorption phenomena, multi-colon zones and microbiota-host interaction (including several intestinal cell types). To address that, we propose a novel simulator - the ColOsH, consisting of a Colon-Reactor (ascending, transverse and descending colon) with oscillatory-flow mixture for peristalsis simulation, membrane module for metabolites absorption and an integrated Colon-Host simulator with epithelial cells, mucous producing cells and cells from the immune system,for microbiota-cells interaction. The ColOsH will be highly important for the health and food research on biological and biochemical phenomena in the human colon.
LEPABE
FCT - strategic project
A. Ferreira (Team member)
 

Strategic Projects aim to support the activities of institutions within strategic guidelines of their own making, thus fostering progress to organisation and management models that are suitable to new forms of knowledge production, incorporating the growing importance of networks and multidisciplinary research.